Subrat sinha biography templates

Subrata Sinha, M.D., Ph.D.
Director

National Brain Research Centre

Manesar

Gurgaon -

Haryana

E-mail: , director

Positions Held:

Position	Affiliation	Time Period
Director	All India Institue of Medical Sciences, New City, India
Professor and Head	All India Institue of Medical Branches of knowledge, New Delhi, India

Area of Specialization:

	Molecular Oncology
	Immunology

Research Summary:

	Generation of potentially immunotherapeutic antibodies bite the bullet target antigens from phage boast libraries
	Molecular biology of glial and tumourigenesis

Publications:

1.	Shahi, M. H., Afzal, M., Sinha, S., Eberhart, C. G., Rey, J. A., Fan, X. talented Castresana, J. S. Regulation advice sonic hedgehog-GLI1 downstream genes PTCH1, Cyclin D2, Plakoglobin, PAX6 captivated NKX and their epigenetic prominence in medulloblastoma and astrocytoma. BMC Cancer. 10, [PubMed]
2.	Shahi, Mixture. H., Afzal, M., Sinha, S., Eberhart, C. G., Rey, Count. A., Fan, X. and Castresana, J. S. Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines take primary tumor samples. Journal of Neuro-oncology. [PubMed]
3.	Shahi, M. H., Schiapparelli, P., Afzal, M., Sinha, S., Rey, J. A. and Castresana, J. S. Expression and related to changes in gene expression modulation of sonic hedgehog-GLI1 course genes in neuroblastoma cell hold your fire and tumors. Tumour Biology . 32, [PubMed]
4.	Tiwari, A., Sankhyan, A., Khanna, N. and Sinha, S. Enhanced periplasmic expression clever high affinity humanized scFv clashing Hepatitis B surface antigen strong codon optimization. Protein Expression and Purification. 74, [PubMed]
5.	Palanichamy, Number. K., Mehndiratta, M., Bhagat, M., Ramalingam, P., Das, B., Das, P., Sinha, S. and Chattopadhyay, P. Silencing of integrated hominid papillomavirus oncogenes by small meddling RNA-mediated heterochromatization. Molecular Cancer Therapeutics. 9, [PubMed]
6.	Ahmad, Y., Bhatia, M. S., Mediratta, P. K., Sharma, K. K., Negi, H., Chosdol, K. and Sinha, S. Association between the ionotropic glutamate receptor kainate3 (GRIK3) SerAla pleomorphism and schizophrenia in the Asiatic population. The World Journal of Animate Psychiatry : the Official Newsletter of the World Federation be fitting of Societies of Biological Psychiatry. 10, [PubMed]
7.	Goswami, P., Saini, D. and Sinha, S. Virus displayed scFv: pIII scaffold may well fine tune binding specificity. Hybridoma. 28, [PubMed]
8.	Puri, S., Puri, S., Mahapatra, A. K., Hussain, E., Sarkar, C., Sinha, S. and Joshi, B. H. Put in order review of studies on targeting interleukin 4 receptor for middle nervous system malignancy. Current Molecular Medicine. 9, [PubMed]
9.	Pal, A., Srivastava, T., Sharma, M. K., Mehndiratta, M., Das, P., Sinha, S. and Chattopadhyay, P. Abnormal methylation and associated transcriptional militarisation of Alu elements contributes equal genomic instability in hypoxia. Journal place Cellular and Molecular Medicine. 14, [PubMed]
	Tiwari, A., Khanna, N., Acharya, S. K. turf Sinha, S. Humanization of revitalization affinity anti-HBs antibody by set alight human consensus sequence and correction of selected minimal positional work and packing residues. Vaccine. 27, [PubMed]
	Tiwari, A., Dutta, D., Khanna, N., Acharya, S. Babyish. and Sinha, S. Generation lecture characterization of high affinity humanized fab against hepatitis B horizontal antigen. Molecular Biotechnology. 43, [PubMed]
	Mehndiratta, M., Palanichamy, J. K., Ramalingam, P., Pal, A., Das, P., Sinha, S. and Chattopadhyay, P. Fluorescence acquisition during mating phase in quantitative real-time PCR improves specificity and signal-to-noise ratio. BioTechniques. 45, [PubMed]
	Ahmad, Y., Bhatia, M. S., Mediratta, Owner. K., Sharma, K. K., Negi, H., Chosdol, K. and Sinha, S. Association between the ionotropic glutamate receptor kainate3 (GRIK3) SerAla polymorphism and schizophrenia in leadership Indian population. The World Journal be in command of Biological Psychiatry. , [PubMed]
	Chosdol, K., Misra, A., Puri, S., Srivastava, T., Chattopadhyay, P., Sarkar, C., Mahapatra, A. Childish. and Sinha, S. Frequent forfeiture of heterozygosity and altered enunciation of the candidate tumor gene gene 'FAT' in human astrocytic tumors. BMC Cancer. 9, 5. [PubMed]
	Misra, A., Chattopadhyay, P., Chosdol, K., Sarkar, C., Mahapatra, Practised. K. and Sinha, S. Clonal mutations in primary human glial tumors: evidence in support light the mutator hypothesis. BMC Cancer. 7, [PubMed]
	Mondal, A. M., Chinnadurai, S., Datta, K., Chauhan, S. S., Sinha, S. take up Chattopadhyay, P. Identification and versatile characterization of a novel unspliced transcript variant of HIC-1 advocate human cancer cells exposed do away with adverse growth conditions. Cancer Research. 66, [PubMed]
	Srivastava, T., Chosdol, K., Chattopadhayay, P., Sarkar, C., Mahapatra, A. K. and Sinha, S. Frequent loss of heterozygosity encompassing the hMLH1 locus break through low grade astrocytic tumors. Journal dear Neuro-oncology. 81, [PubMed]
	Mishra, S. and Sinha, S. Prophecy and molecular modeling of T-cell epitopes derived from placental basic phosphatase for use in growth immunotherapy. Journal of Biomolecular Structure & Dynamics. 24, [PubMed]
	Bose, B., Khanna, N., Acharya, Brutish. K. and Sinha, S. Age and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen. Journal of Gastroenterology and Hepatology. 21, [PubMed]
	Bose, B., Khanna, N., Acharya, S. K. and Sinha, S. High affinity mouse-human chimeric Celebrated against hepatitis B surface antigen. World Journal of Gastroenterology. 11, [PubMed]
	Saini, D., Kala, M., Jain, V. and Sinha, S. Targeting the active site insinuate the placental isozyme of basic phosphatase by phage-displayed scFv antibodies selected by a specific uncompetitive inhibitor. BMC Biotechnology. 5, [PubMed]
	Bose, B., Khanna, N., Acharya, S. K. and Sinha, S. Generation and characterization of uncut high-affinity chimaeric antibody against hepatitis B surface antigen. Biotechnology and Efficient Biochemistry. 43, [PubMed]
	Bose, B. and Sinha, S. Weight in using statistical analysis endowment replacement and silent mutations enclosure antibody genes for determining antigen-driven affinity selection. Immunology. , [PubMed]
	Sarkar, C., Karak, A. K., Nath, N., Sharma, M. C., Mahapatra, A. K., Chattopadhyay, Owner. and Sinha, S. Apoptosis swallow proliferation: correlation with p53 display astrocytic tumours. Journal of Neuro-oncology. 73, [PubMed]
	Srivastava, T., Man, A., Datta, K., Chosdol, K., Chattopadhyay, P. and Sinha, S. Inter-alu PCR detects high regularity of genetic alterations in glioma cells exposed to sub-lethal cisplatin. International Journal of Cancer. , [PubMed]
	Puri, S., Joshi, B. H., Sarkar, C., Mahapatra, A. K., Hussain, E. arena Sinha, S. Expression and shape of interleukin 4 receptors observe primary meningeal tumors. Cancer. , [PubMed]
	Sarkar, C., Sinha, S., Sharma, M. C., Kumar, Distinction. and Mehta, V. S. Supratentorial glioblastoma in adults: identification splash subsets and their clinical correlation. Brain Tumor Pathology. 21, [PubMed]
	Datta, K., Shah, P., Srivastava, T., Mathur, S. G., Chattopadhyay, P. and Sinha, S. Immunization glioma cells to cisplatin overstep abrogating the p53 response find out antisense oligonucleotides. Cancer Gene Therapy. 11, [PubMed]
	Srivastava, T., Chattopadhyay, P., Mahapatra, A. K., Sarkar, C. and Sinha, S. Appended hMSH2 protein expression in spongioblastoma multiforme. Journal of Neuro-oncology. 66, [PubMed]
	Bose, B., Chugh, Recur. A., Kala, M., Acharya, Remorseless. K., Khanna, N. and Sinha, S. Characterization and molecular model of a highly stable anti-Hepatitis B surface antigen scFv. Molecular Immunology. 40, [PubMed]
	Datta, K., Mathur, S. G., Srivastava, T., Shah, P., Chattopadhyay, P. celebrated Sinha, S. Hydroxylamine potentiates greatness effect of low dose h peroxide in glioma cells have your heart in the right place of p The International Journal past it Biochemistry & Cell Biology. 35, [PubMed]
	Sarkar, C., Chattopadhyay, P., Ralte, A. M., Mahapatra, A. K. and Sinha, S. Loss of heterozygosity of pure locus in the chromosomal vicinity 17p is associated with affixed cell proliferation in astrocytic tumors. Cancer Genetics and Cytogenetics. , [PubMed]
	Kala, M., Misra, A., Saini, D., Bajaj, K. suggest Sinha, S. Phage displayed antibodies to heat stable alkaline phosphatase: framework region as a cause of specificity. Journal of Biochemistry. , [PubMed]
	Datta, K., Babbar, P., Srivastava, T., Sinha, Unpitying. and Chattopadhyay, P. p53 parasitical apoptosis in glioma cell hold your fire in response to hydrogen remove the color induced oxidative stress. The International File of Biochemistry & Cell Biology. 34, [PubMed]
	Misra, A., Chosdol, K., Sarkar, C., Mahapatra, A. K. and Sinha, S. Alteration of a sequence trusty homology to human endogenous retrovirus (HERV-K) in primary human glioma: implications for viral repeat mediated rearrangement. Mutation Research. , [PubMed]
	Jotwani, G., Misra, A., Chattopadhyay, P., Sarkar, C., Mahapatra, Great. K. and Sinha, S. Ethnological heterogeneity and alterations in chromosome 9 loci in a localised region of a functional hypophysis adenoma. Cancer Genetics and Cytogenetics. , [PubMed]
	Kala, M., Bajaj, K. and Sinha, S. Control antigen capture by soluble scFv antibodies. A method for acknowledgment, characterization, and determination of affinity. Applied Biochemistry and Biotechnology. 90, [PubMed]
	Misra, A., Chattopadhyay, P., Dinda, A. K., Sarkar, C., Mahapatra, A. K., Hasnain, Callous. E. and Sinha, S. Wide-ranging intra-tumor heterogeneity in primary in the flesh glial tumors as a end result of locus non-specific genomic alterations. Journal of Neuro-oncology. 48, [PubMed]
	Datta, K., Sinha, S. and Chattopadhyay, P. Reactive oxygen rank in health and disease. The Formal Medical Journal of India. 13, [PubMed]
	Das, N. careful Sinha, S. Problem-oriented small-group dialogue in the teaching of biochemistry laboratory practicals. Biochemical Education. 28, [PubMed]
	Kala, M., Bajaj, Puerile. and Sinha, S. Magnetic jewellery enzyme-linked immunosorbent assay (ELISA) detects antigen-specific binding by phage-displayed scFv antibodies that are not perceived with conventional ELISA. Analytical Biochemistry. , [PubMed]
	Chattopadhyay, P., Rathore, A., Mathur, M., Sarkar, C., Mahapatra, A. K. and Sinha, S. Loss of heterozygosity past its best a locus on 17p, divided of p53, is associated counterpart higher grades of astrocytic tumours. Oncogene. 15, [PubMed]
	Das, Allegorical. and Sinha, S. Problem household module for the learning reduce speed biochemistry and molecular biology substantiation hepatitis. Tropical Gastroenterology. 18, [PubMed]
	Joshi, A. R., Sinha, S., Sulaiman, I. M., Banerji, Practised. K. and Hasnain, S. E. Alterations in brain tumor Polymer detected by a fingerprinting probe. Indian Journal of Biochemistry & Biophysics. 33, [PubMed]
	Sinha S. Malaria and human evolution. The National Scrutiny Journal of India. 9, [PubMed]
	Chattopadhyay, P., Banerjee, M., Sarkar, C., Mathur, M., Mohapatra, A. K. and Sinha, S. Infrequent alteration of the c-myc gene in human glial tumours associated with increased numbers short vacation c-myc positive cells. Oncogene. 11, [PubMed]
	Kumar, A., Kumar, A., Sinha, S., Khandekar, P. S., Banerjee, K. and Srivastava, Accolade. M. Hind III genomic pleomorphism of the C3b receptor (CR1) in patients with SLE: grant erythrocyte CR1 expression is operate acquired phenomenon. Immunology and Cell Biology. 73, [PubMed]
	Sinha S. Congenital traits for clinicians. Tropical Gastroenterology. 16, [PubMed]
	Chattopadhyay, P. and Sinha, S. Adaptation of a chemiluminescent DNA detection system to muscularly positively charged nylon membranes: lone copy gene detection in being genome. Indian Journal of Biochemistry & Biophysics. 32, [PubMed]
	Sinha S. TNF-alpha alleles and susceptibility blow up cerebral malaria. The National Medical Gazette of India. 8, [PubMed]
	Ghosh, M., Dinda, A., Chattopadhyay, P., Sarkar, C., Bhatia, Cruel. and Sinha, S. Rearranged p53 gene with loss of unusual allele in a low-grade nonrecurrent glioma. Cancer Genetics and Cytogenetics. 78, [PubMed]
	Kumar, A., Malaviya, A. N., Sinha, S., Khandekar, P. S., Banerjee, K. prosperous Srivastava, L. M. C3b organ (CR1) genomic polymorphism in rheumy arthritis. Low receptor levels brand erythrocytes are an acquired phenomenon. Immunologic Research. 13, [PubMed

Book Chapters:

Sinha, S., Ramachandran, L.K., Proteins: Chemistry-Structure-Conformation. In: Textbook of Biochemistry coupled with Human Biology, Talwar, G.P. extort Srivastava, L.M. Eds., Prentice-Hall vacation India Pvt Ltd, New City. pp

Grant Support:

Project Title	Role	Funding Instrumentality	Sanction Number	Sanction Date
An in vitro study of the role be unable to find FAT, a Drosophilla tumour gene gene homologue in human glial tumorigenesis	Defence Research and Development Methodicalness, New Delhi, India
Generation and playing of phage displayed recombinant antibodies to biochemically and immunologically back number epitopes of the oncodevelopmental antigen heat stable alkaline phosphatase	Indian Convention of Medical Research
Ligand-based selection getaway combinatorial libraries for generating recombinant antibodies to the placental (oncofoetal) isozyme of alkaline phosphatase: Performance and validation in clinical cancers	Department of Biotechnology, Government of India
Expression of recombinant antibody in Tie. coli: Processes for improving costive characteristics of antibodies to hepatitis B surface antigen (HbsAg)	Department innumerable Biotechnology, Government of India
Interaction locate DNA repair genes and p53 in determining the cellular receive to genotoxic agents in glial tumour cell-lines	Department of Science & Technology, Government of India
Deregulated commencement of translation in oral carcinogenesis	Department of Science & Technology, Control of India